Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Sep 17;12(18):4176-9.
doi: 10.1021/ol1017799.

Diamine-free lithiation-trapping of N-Boc heterocycles using s-BuLi in THF

Graeme Barker  1 , Peter O'Brien, Kevin R Campos
Affiliations

Diamine-free lithiation-trapping of N-Boc heterocycles using s-BuLi in THF

Graeme Barker et al. Org Lett. .

Abstract

A diamine-free protocol for the s-BuLi-mediated lithiation-trapping of N-Boc heterocycles has been developed. In the optimized procedure, lithiation is accomplished using s-BuLi in THF at -30 °C for only 5 or 10 min. Subsequent electrophilic trapping or transmetalation-Negishi coupling delivered a range of functionalized pyrrolidines, imidazolidines, and piperazines in 43-83% yield.

PubMed Disclaimer

Publication types

LinkOut - more resources