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Randomized Controlled Trial
. 2010 Oct;12(10):754-9.
doi: 10.1016/j.jfms.2010.05.012. Epub 2010 Aug 16.

Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats

Amy E DeClue  1 , Claire R Sharp, Rachael L Cohen, Elizabeth F Leverenz, Carol R Reinero
Affiliations
Randomized Controlled Trial

Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats

Amy E DeClue et al. J Feline Med Surg. 2010 Oct.

Abstract

This study evaluated the effects of a cysteinyl-leukotriene-1 (cys-LT(1)) receptor antagonist, zarfirlukast, during feline endotoxemia. Six adult, sexually intact male cats received either placebo or zarfirlukast (10mg, PO) and endotoxin (2 μg/kg/h q 6h) in a cross-over design. Rectal temperature, heart rate, systolic arterial blood pressure, plasma tumor necrosis factor (TNF) activity, interleukin (IL)-6 concentration and urine cys-LT to creatinine ratio were evaluated. The rectal temperature, plasma TNF activity and IL-6 concentrations were significantly higher and systolic arterial blood pressure and heart rate significantly lower after endotoxin infusion. Cats treated with zafirlukast had a significantly higher blood pressure at 4h (P=0.002) compared to placebo. Urine cys-LT to creatinine ratio was significantly greater in the cats treated with zafirlukast compared to placebo (P=0.02). Zafirlukast administration ameliorated the acute hypotensive response to endotoxin in cats, but failed to significantly alter rectal temperature, heart rate or production of TNF and IL-6.

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References

    1. Brady C.,Otto C.,Winkle T.,King L..Severe sepsis in cats: 29 cases (1986–1998).J Am Vet Med Assoc. 2000;217:531-535 - PubMed
    1. CostelloM.Sepsis panel – feline sepsis. ACVECC Postgraduate Course 2006: sepsis in veterinary medicine, 2006, San Francisco, CA
    1. Sergeeff J.,Armstrong P.J.,Bunch S.E..Hepatic abscesses in cats: 14 cases (1985–2002).J Vet Intern Med. 2004;18:295-300 - PubMed
    1. Costello M.,Drobatz K.,Aronson L..Underlying cause, pathophysiologic abnormalities, and response to treatment in cats with septic peritonitis: 51 cases (1990–2001).J Am Vet Med Assoc. 2004;225:897-902 - PubMed
    1. DeClueADelgadoCChangCSharpC. Clinical and immunologic assessment of sepsis and the systemic inflammatory response syndrome in cats. J Am Vet Med Assoc. In press 2010. - PubMed

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