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Review
. 2010 Oct;16(10):1865-9.
doi: 10.1261/rna.2266510. Epub 2010 Aug 18.

Regulatory RNAs derived from transfer RNA?

Thoru Pederson  1
Affiliations
Review

Regulatory RNAs derived from transfer RNA?

Thoru Pederson. RNA. 2010 Oct.

Abstract

Four recent studies suggest that cleavages of transfer RNAs generate products with microRNA-like features, with some evidence of function. If their regulatory functions were to be confirmed, these newly revealed RNAs would add to the expanding repertoire of small noncoding RNAs and would also provide new perspectives on the coevolution of transfer RNA and messenger RNA.

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References

    1. Baer M, Nilsen TW, Costigan C, Altman S 1990. Structure and transcription of a human gene for H1 RNA, the RNA component of human RNase P. Nucleic Acids Res 18: 97–103 - PMC - PubMed
    1. Babiarz JE, Ruby JG, Wang Y, Bartel DP, Blelloch R 2008. Mouse ES cells express endogenous shRNAs, siRNAs, and other micro-processor-independent, Dicer-dependent small RNAs. Genes Dev 22: 2773–2785 - PMC - PubMed
    1. Bertrand E, Houser-Scott F, Kendall A, Singer RH, Engelke DR 1998. Nucleolar localization of early tRNA processing. Genes Dev 12: 1263–1264 - PMC - PubMed
    1. Buhler M, Spies N, Bartel DP, Moazed D 2008. TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway. Nat Struct Mol Biol 15: 1015–1023 - PMC - PubMed
    1. Calabrese JM, Seila AC, Yoo GW, Sharp PA 2007. RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Proc Natl Acad Sci 104: 18097–18102 - PMC - PubMed

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