Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2010 Sep;30(9):1682-3.
doi: 10.1161/ATVBAHA.110.210633.

Notch leads lymphatics and links them to blood vessels

Shan Liao, Timothy P Padera, Rakesh K Jain
Editorial

Notch leads lymphatics and links them to blood vessels

Shan Liao et al. Arterioscler Thromb Vasc Biol. 2010 Sep.
No abstract available

PubMed Disclaimer

Figures

Figure
Figure
Notch links blood and lymphatic vessels. Notch is involved in critical steps of lymphangiogenesis during embryogenesis: endothelial cell fate decision (1) and LEC sprouting from the cardinal vein (2). Geudens et al. also show that lymphatic vessel patterning is guided by arterial vasculature and that this process may be mediated by Notch (3, 4).
See this image and copyright information in PMC

Comment on

  • Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.
    Geudens I, Herpers R, Hermans K, Segura I, Ruiz de Almodovar C, Bussmann J, De Smet F, Vandevelde W, Hogan BM, Siekmann A, Claes F, Moore JC, Pistocchi AS, Loges S, Mazzone M, Mariggi G, Bruyère F, Cotelli F, Kerjaschki D, Noël A, Foidart JM, Gerhardt H, Ny A, Langenberg T, Lawson ND, Duckers HJ, Schulte-Merker S, Carmeliet P, Dewerchin M. Geudens I, et al. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1695-702. doi: 10.1161/ATVBAHA.110.203034. Epub 2010 May 13. Arterioscler Thromb Vasc Biol. 2010. PMID: 20466977 Free PMC article.

References

    1. Oliver G, Srinivasan RS. Endothelial cell plasticity: How to become and remain a lymphatic endothelial cell. Development. 2010;137:363–372. - PMC - PubMed
    1. Tammela T, Alitalo K. Lymphangiogenesis: Molecular mechanisms and future promise. Cell. 2010;140:460–476. - PubMed
    1. Geudens I, Herpers R, Hermans K, Segura I, Ruiz de Almodovar C, Bussmann J, De Smet F, Vandevelde W, Hogan BM, Siekmann A, Claes F, Moore JC, Pistocchi AS, Loges S, Mazzone M, Mariggi G, Bruyere F, Cotelli F, Kerjaschki D, Noel A, Foidart JM, Gerhardt H, Ny A, Langenberg T, Lawson ND, Duckers HJ, Schulte-Merker S, Carmeliet P, Dewerchin M. Role of dll4/notch in the formation and wiring of the lymphatic network in zebra fish. Arterioscler Thromb Vasc Biol. 2010 Epub ahead of print. - PMC - PubMed
    1. Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, Wirzenius M, Waltari M, Hellstrom M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Yla-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K. Blocking vegfr-3 suppresses angiogenic sprouting and vascular network formation. Nature. 2008;454:656–660. - PubMed
    1. Francois M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, Paavonen K, Karnezis T, Shayan R, Downes M, Davidson T, Tutt D, Cheah KS, Stacker SA, Muscat GE, Achen MG, Dejana E, Koopman P. Sox18 induces development of the lymphatic vasculature in mice. Nature. 2008;456:643–647. - PubMed

MeSH terms