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Review
. 2010 Sep;10(9):618-29.
doi: 10.1038/nrc2900. Epub 2010 Aug 19.

Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

Walter Kolch  1 , Andrew Pitt
Affiliations
Review

Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

Walter Kolch et al. Nat Rev Cancer. 2010 Sep.

Abstract

Advances in the generation and interpretation of proteomics data have spurred a transition from focusing on protein identification to functional analysis. Here we review recent proteomics results that have elucidated new aspects of the roles and regulation of signal transduction pathways in cancer using the epidermal growth factor receptor (EGFR), ERK and breakpoint cluster region (BCR)-ABL1 networks as examples. The emerging theme is to understand cancer signalling as networks of multiprotein machines which process information in a highly dynamic environment that is shaped by changing protein interactions and post-translational modifications (PTMs). Cancerous genetic mutations derange these protein networks in complex ways that are tractable by proteomics.

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