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Comment
. 2010 Aug 20;142(4):511-2.
doi: 10.1016/j.cell.2010.08.004.

Reversing cachexia

Michael J Tisdale  1
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Free article
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Reversing cachexia

Michael J Tisdale. Cell. .
Free article

Abstract

Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor.

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