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Comment
. 2010 Aug 20;142(4):517-8.
doi: 10.1016/j.cell.2010.08.002.

The Immunoproteasome Cleans up after Inflammation

Sjoerd van Deventer  1 , Jacques Neefjes
Affiliations
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The Immunoproteasome Cleans up after Inflammation

Sjoerd van Deventer et al. Cell. .

Abstract

Immune cells and cells activated by the inflammatory cytokine interferon express variant proteasomes called immunoproteasomes that are characterized by unique catalytic subunits. Seifert et al. (2010) now show in mouse models of inflammatory disease that immunoproteasomes help prevent the accumulation of harmful protein aggregates.

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