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. 2010 Nov;213(1):329-31.
doi: 10.1016/j.atherosclerosis.2010.07.026. Epub 2010 Jul 27.

Fatty acid-binding protein 4 is associated with endothelial dysfunction in patients with type 2 diabetes

Gemma Aragonès  1 , Raimon Ferré, Iolanda Lázaro, Anna Cabré, Núria Plana, Jordi Merino, Mercedes Heras, Josefa Girona, Lluís Masana
Affiliations

Fatty acid-binding protein 4 is associated with endothelial dysfunction in patients with type 2 diabetes

Gemma Aragonès et al. Atherosclerosis. 2010 Nov.

Abstract

Objective: Adipocyte fatty acid-binding protein (FABP4) plasma levels are higher in type 2 diabetes (T2D). Endothelial dysfunction is also common in T2D. We have investigated the relationship between circulating FABP4 levels and endothelial function in diabetic patients.

Methods: In 257 patients (105 diabetic and 152 non-diabetic) at increased risk of cardiovascular disease, we measured circulating FABP4, reactive hyperemia index (RHI) by peripheral artery tonometry, intima-media thickness, and biomarkers of inflammation, oxidation and endothelial function.

Results: In T2D subjects, FABP4 was negatively associated with endothelial function, as measured by RHI (r=-0.226, P=0.05). In a stepwise multivariate linear regression model, FABP4 was a predictor of RHI in T2D patients (P=0.04).

Conclusion: Circulating levels of FABP4 are inversely associated with endothelial function in T2D patients, as measured by RHI. We suggest a direct effect of plasma FABP4 on the vascular endothelium in those with T2D.

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