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. 1991 Aug;65(8):4547-9.
doi: 10.1128/JVI.65.8.4547-4549.1991.

Transcellular transactivation by the human immunodeficiency virus type 1 tat protein

D E Helland  1 , J L Welles, A Caputo, W A Haseltine
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Transcellular transactivation by the human immunodeficiency virus type 1 tat protein

D E Helland et al. J Virol. 1991 Aug.

Abstract

The human immunodeficiency virus type 1 (HIV-1) transactivator (tat) protein produced in one cell activated HIV-1 promoter-directed gene expression in a second cell, provided the cells were in direct contact with one another. This observation suggests that the tat protein produced in HIV-1-infected cells has a physiological effect on neighboring cells.

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