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. 2010 Oct;100(10):1867-76.
doi: 10.2105/AJPH.2009.184796. Epub 2010 Aug 19.

Antiretroviral therapy as HIV prevention: status and prospects

Kenneth H Mayer  1 , Kartik K Venkatesh
Affiliations

Antiretroviral therapy as HIV prevention: status and prospects

Kenneth H Mayer et al. Am J Public Health. 2010 Oct.

Abstract

As antiretroviral treatment of HIV infection has become increasingly accessible, attention has focused on whether these drugs can used for prevention because of increased tolerability of newer medications, decreased cost, and the limitations of other approaches. We review the status of antiretroviral HIV prevention, including chemoprophylaxis, as well as the effects of treatment of infected individuals on prevention. It is possible that the life-saving agents that have transformed the natural history of AIDS can be a critical component of HIV prevention efforts, but their ultimate role in affecting HIV transmission dynamics remains to be defined.

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Figures

FIGURE 1
FIGURE 1
Potential approaches to prevent HIV transmission. Note. HAART = highly active antiretroviral therapy; PEP = postexposure prophylaxis; PrEP = preexposure prophylaxis; STI = sexually transmitted infection. Bolded items are those that use antiretroviral agents.
FIGURE 2
FIGURE 2
Potential effects of highly active antiretroviral therapy on HIV transmission. Note. HAART = highly active antiretroviral therapy; STI = sexually transmitted infection.
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