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. 2010 Jul;3(7):20-31.

Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color

Erica C Davis, Valerie D Callender

Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color

Erica C Davis et al. J Clin Aesthet Dermatol. 2010 Jul.

Abstract

Postinflammatory hyperpigmentation is a common sequelae of inflammatory dermatoses that tends to affect darker skinned patients with greater frequency and severity. Epidemiological studies show that dyschromias, including postinflammatory hyperpigmentation, are among the most common reasons darker racial/ethnic groups seek the care of a dermatologist. The treatment of postinflammatory hyperpigmentation should be started early to help hasten its resolution and begins with management of the initial inflammatory condition. First-line therapy typically consists of topical depigmenting agents in addition to photoprotection including a sunscreen. Topical tyrosinase inhibitors, such as hydroquinone, azelaic acid, kojic acid, arbutin, and certain licorice extracts, can effectively lighten areas of hypermelanosis. Other depigmenting agents include retinoids, mequinol, ascorbic acid, niacinamide, N-acetyl glucosamine, and soy with a number of emerging therapies on the horizon. Topical therapy is typically effective for epidermal postinflammatory hyperpigmentation; however, certain procedures, such as chemical peeling and laser therapy, may help treat recalcitrant hyperpigmentation. It is also important to use caution with all of the above treatments to prevent irritation and worsening of postinflammatory hyperpigmentation.

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Figures

Figure 1
Figure 1
Postinflammatory hyperpigmentation after light electrodessication for dermatosis papulosa nigra
Figure 2
Figure 2
Acne-induced PIH in a patient with Fitzpatrick skin type V
Figure 3
Figure 3
African-American female with hirsutism and pseudofolliculitis barbae with PIH
Figures 4A and 4B
Figures 4A and 4B
Postinflammatory hyperpigmentation in Fitzpatrick skin type IV (A) versus VI (B). Note the greater intensity of pigmentation in darker skin.
Figures 4A and 4B
Figures 4A and 4B
Postinflammatory hyperpigmentation in Fitzpatrick skin type IV (A) versus VI (B). Note the greater intensity of pigmentation in darker skin.
Figure 5
Figure 5
Exogenous ochronosis
See this image and copyright information in PMC

References

    1. Chang MW. Disorders of hyperpigmentation. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd ed. Elsevier Mosby; 2009. pp. 333–389.
    1. Halder RM, Grimes PE, McLaurin CI, et al. Incidence of common dermatoses in a predominately black dermatologic practice. Cutis. 1983;32:388–390. - PubMed
    1. Alexis AF, Sergay AB, Taylor SC. Common dermatologic disorders in skin of color: a comparative practice survey. Cutis. 2007;80:387–394. - PubMed
    1. Chua-Ty G, Goh CL, Koh SL. Pattern of skin diseases at the national skin centre (Singapore) from 1989–1990. Int J Dermatol. 1992;31:555–559. - PubMed
    1. Taylor SC, Grimes PE, Lim J, et al. Postinflammatory Hyperpigmentation. J Cutan Med Surg. 2009;13:183–191. - PubMed

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