Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2010 May;3(5):32-5.

Severe Acute Local Reactions to a Hyaluronic Acid-derived Dermal Filler

Susan Van Dyke, Geoffrey P Hays, Anthony E Caglia, Michael Caglia
Case Reports

Severe Acute Local Reactions to a Hyaluronic Acid-derived Dermal Filler

Susan Van Dyke et al. J Clin Aesthet Dermatol. 2010 May.

Abstract

Injectable fillers are normally well tolerated by patients with little or no adverse effects. The most common side effects include swelling, redness, bruising, and pain at the injection site. This report describes three cases in which patients injected with a hyaluronic acid-derived injectable filler that is premixed with lidocaine developed adverse reactions including persistent swelling, pain, and nodule formation. Two of the three patients' abscesses were cultured for aerobic and anaerobic bacteria and mycobacterium. All three cultures were negative. Abscess persistence in all cases necessitated physical removal and/or enzymatic degradation with hyaluronidase. The effects subsided only after the product had been removed. Two of these patients were subsequently treated with other hyaluronic acid-derived dermal fillers without adverse events.

PubMed Disclaimer

Figures

Figures 1
Figures 1
Graphic timeline of Case Report 1 showing medications, treatments, and procedures provided relative to the initial Elevess treatment.
Figure 2
Figure 2
Patient from Case Report 1 treated with Elevess. Photo taken 32 days after initial Elevess treatment.
Figure 3
Figure 3
Patient before Elevess treatment (left), after Elevess treatment to nasolabial and infraorbital areas (middle), and after treatment with hyaluronidase (right).
Figure 4
Figure 4
Adverse reaction to Elevess at treatment site including severe edema and recurring nodules.
See this image and copyright information in PMC

References

    1. Andre P, Lowe N, Parc A, Clerici T, Zimmermann U. Adverse reactions to dermal fillers: a review of European experiences. J Cosmet Laser Ther. 2005;7:171–176. - PubMed
    1. Bachmann F, Erdmann R, Hartmann V, Wiest L, Rzany B. The spectrum of adverse reactions after treatment with injectable filler in the glabellar region: results from the injectable filler safety study. Dermatol Surg. 2009;35:1629–1634. - PubMed
    1. Glaich AS, Cohen JL, Goldberg LH. Injection necrosis of the glabella: protocol for prevention and treatment after use of dermal fillers. Dermatol Surg. 2006;32(2):276–281. - PubMed
    1. Rossner F, Rossner M, Hartmann V, et al. Decrease of reported adverse events of injectable polylactic acid after recommending an increased dilution: 8-year results from the Injectable Filler Safety Study. J Cosmet Dermatol. 2009;8(1):14–18. - PubMed
    1. Friedman PM, Mafong EA, Kauvar ANB, Geronemus RG. Safety data of injectable nonanimal stabilized hyaluronic acid gel for soft tissue augmentation. Dermatol Surg. 2002;28(6):491–494. - PubMed

Publication types

LinkOut - more resources