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. 2010 Sep;49(9):1124, 1126-8, 1130.
doi: 10.1007/s00120-010-2370-0.

[Antiandrogen strategies in prostate cancer: reconstitution of oestrogen receptor beta]

[Article in German]
P Thelen  1 , A Strauss, M Stettner, S Kaulfuss, R-H Ringert, H Loertzer
Affiliations

[Antiandrogen strategies in prostate cancer: reconstitution of oestrogen receptor beta]

[Article in German]
P Thelen et al. Urologe A. 2010 Sep.

Abstract

In advanced prostate cancer, albeit castration resistant, an active androgen receptor is still pivotal for growth and cell survival. Recent therapies involving more effective antiandrogens such as MDV3100 proved to be successful. Furthermore, blocking de novo intracrine androgen synthesis, e.g. with abiraterone acetate, provides additional benefit. Besides these antiandrogen measures, compounds which enable the reconstitution of the oestrogen receptor beta as a tumour suppressor restrain aberrant androgen receptor signalling.

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