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Review
. 2010 Dec;48(1-3):110-21.
doi: 10.1007/s12026-010-8171-0.

Quiescent T cells and HIV: an unresolved relationship

Dimitrios N Vatakis  1 , Christopher C Nixon, Jerome A Zack
Affiliations
Review

Quiescent T cells and HIV: an unresolved relationship

Dimitrios N Vatakis et al. Immunol Res. 2010 Dec.

Abstract

The ability of HIV to infect quiescent CD4+ T cells has been a topic of intense debate. While early studies suggested that the virus could not infect this particular T cell subset, subsequent studies using more sensitive protocols demonstrated that these cells could inefficiently support HIV infection. Additional studies showed that the kinetics of infection in quiescent cells was delayed and multiple stages of the viral life cycle were marred by inefficiencies. Despite that, proviral DNA has been found in these cells presenting them as a potential viral reservoir. Therefore, a better understanding of the relationship between HIV and quiescent T cells may lead to further advances in the field of HIV.

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Figures

Fig. 1
Fig. 1
Identification of the different cell cycle phases following CD4 T cell stimulation. Quiescent CD4 T cells are purified and stimulated for 3 days using anti-CD3/anti-CD28. This is a representative figure of T cell cycle progression. Cells are harvested and stained with 7AAD (y-axis, lin fluorescence) (DNA) and Pyronin Y (x-axis, lin fluorescence) (RNA) and analyzed by flow cytometry. The quadrants are set based on n-butyrate (G1a arrest) and aphidocolin (G1b arrest) treatment of these cells
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