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. 1978 Apr 15;172(1):177-9.
doi: 10.1042/bj1720177.

Complete loss of heparin-releasable triacylglycerol lipase activity after collagenase treatment of the rat liver

J Thomas, L J Debeer, G P Mannaerts

Complete loss of heparin-releasable triacylglycerol lipase activity after collagenase treatment of the rat liver

J Thomas et al. Biochem J. .

Abstract

Lipolytic activity at pH 8.5-9.5 was lowered by approx. 80% in homogenates from livers perfused with collagenase or heparin. No heparin-releasable lipase activity was detected in hepatocytes isolated by collagenase treatment. It is concluded that crude collagenase completely inactivates the plasma-membrane-bound heparin-releasable lipase.

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