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. 2010 Sep 21;49(37):7972-4.
doi: 10.1021/bi100409w.

The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis

Jing Wang  1 , Stefan Steinbacher, Martin Augustin, Patrick Schreiner, David Epstein, Mark J Mulvihill, Andrew P Crew
Affiliations

The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis

Jing Wang et al. Biochemistry. .

Abstract

A complex of RON(M1254T) with AMP-PNP and Mg(2+) reveals a substratelike positioning of Tyr1238 as well as likely catalysis-competent placement of the AMP-PNP and Mg(2+) components and indicates a tendency for cis phosphorylation. The structure shows how the oncogenic mutation may cause the constitutive activation and suggests a mechanistic hypothesis for the autophosphorylation of receptor tyrosine kinases.

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