doi: 10.1021/ol101747n.
Facile synthesis of bicyclic amidines and imidazolines from 1,2-diamines
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- PMID: 20726557
- DOI: 10.1021/ol101747n
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Facile synthesis of bicyclic amidines and imidazolines from 1,2-diamines
Org Lett.
.
Abstract
A facile synthesis of chiral bicyclic amidines and imidazolines from readily available 1,2-diamines has been developed. The reported synthetic strategy relies on an intramolecular cyclization which involves a carboxylic amide derived imidoyl chloride as a key intermediate and aniline serving as a leaving group.
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