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Comment
. 2010;14(4):186.
doi: 10.1186/cc9187. Epub 2010 Aug 3.

The role of inflammation in ICU-acquired weakness

Chris Winkelman  1
Affiliations
Comment

The role of inflammation in ICU-acquired weakness

Chris Winkelman. Crit Care. 2010.

Abstract

A pilot observational study by Weber-Carstens and colleagues contributes to a mechanistic explanation of the puzzling and complex phenomena of ICU-acquired weakness (ICU-AW). The authors suggest systemic, inflammatory-mediated pathology is the most significant risk factor for ICU-AW. While this finding is somewhat equivocal, it provides important direction for future investigations and illustrates the challenges of interpreting significance in small observational studies.

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