doi: 10.1016/j.diagmicrobio.2010.04.011.
In vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureus
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- PMID: 20727462
- DOI: 10.1016/j.diagmicrobio.2010.04.011
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In vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureus
Diagn Microbiol Infect Dis.
2010 Sep.
Abstract
We investigated the activity of tigecycline in combination with gentamicin for the treatment of biofilm-forming methicillin-resistant and sensitive Staphylococcus aureus in an in vitro pharmacodynamic model. Tigecycline monotherapy demonstrated bacteriostatic activity throughout 48 h (-0.24 +/- 0.17 log(10) CFU/mL), whereas tigecycline in combination with gentamicin demonstrated significant (P < 0.002) kill (-3.66 +/- 0.26 log(10) CFU/mL) at 48 h. The addition of gentamicin to tigecycline significantly improved the killing activity of tigecycline in biofilm-forming S. aureus.
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