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. 2010 Dec;81(8):1224-7.
doi: 10.1016/j.fitote.2010.08.006. Epub 2010 Aug 19.

Cytotoxic prenylated flavonoids from Morus alba

Nguyen Tien Dat  1 , Phung Thi Xuan Binh, Le Thi Phuong Quynh, Chau Van Minh, Hoang Thanh Huong, Jung Joon Lee
Affiliations

Cytotoxic prenylated flavonoids from Morus alba

Nguyen Tien Dat et al. Fitoterapia. 2010 Dec.

Abstract

A phytochemical fractionation of the methanol extract of the Morus alba leaves led to the isolation of eleven flavonoids (1-11). The structure of the new 3'-geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone (1) was elucidated by means of spectroscopic methods. The cytotoxicity of the isolated compounds against human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells was evaluated. Of note, morusin (9) was the most potent with an IC(50) value of 0.64 μM against HeLa cells.

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