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. 2010 Sep;16(9):991-4.
doi: 10.1038/nm.2202. Epub 2010 Aug 22.

Advanced antisense therapies for postexposure protection against lethal filovirus infections

Travis K Warren  1 , Kelly L Warfield, Jay Wells, Dana L Swenson, Kelly S Donner, Sean A Van Tongeren, Nicole L Garza, Lian Dong, Dan V Mourich, Stacy Crumley, Donald K Nichols, Patrick L Iversen, Sina Bavari
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Advanced antisense therapies for postexposure protection against lethal filovirus infections

Travis K Warren et al. Nat Med. 2010 Sep.

Abstract

Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show that administration of positively charged phosphorodiamidate morpholino oligomers (PMOplus), delivered by various dosing strategies initiated 30-60 min after infection, protects>60% of rhesus monkeys against lethal Zaire Ebola virus (ZEBOV) and 100% of cynomolgus monkeys against Lake Victoria Marburg virus (MARV) infection. PMOplus may be useful for treating these and other highly pathogenic viruses in humans.

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References

    1. Antimicrob Agents Chemother. 2009 May;53(5):2089-99 - PubMed
    1. Virology. 1998 Nov 10;251(1):28-37 - PubMed
    1. Lancet. 1983 Nov 5;2(8358):1055-8 - PubMed
    1. PLoS Pathog. 2007 Jan;3(1):e2 - PubMed
    1. J Virol. 2009 Jul;83(13):6404-15 - PubMed

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