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. 2009 Mar;2(3):38-43.

Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles

Nathan S Trookman, Ronald L Rizer, Rosanne Ford, Elizabeth Ho, Vincent Gotz

Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles

Nathan S Trookman et al. J Clin Aesthet Dermatol. 2009 Mar.

Abstract

Objective: To evaluate the efficacy and tolerance of a novel line treatment for periocular and perioral wrinkles. The line treatment was formulated with multiple growth factors, antioxidants, and a collagen-building peptide-ingredients that have been shown to increase collagen levels and provide long-term aesthetic benefits. To help provide immediate smoothing effects, hyaluronic acid filling spheres and a muscle contraction-inhibiting peptide were also included in the formulation.

Design: Three-month, single-center, open-label, clinical study with clinical assessments at Baseline, Minutes (within 15 minutes of initial application), Month 1, and Month 3.

Treatment: Subjects treated periocular and perioral wrinkles twice daily for three months with the line treatment.

Participants: Thirty-seven females, 33 to 45 years of age, with mild-to-moderate, fine and coarse periocular and perioral wrinkles, were enrolled in the study.

Measurements: Investigator assessments of fine and coarse periocular and perioral wrinkles, digital photography, and tolerance assessments were conducted at all visits. Subject self-assessment questionnaires were conducted within 15 minutes of initial application and at Month 3.

Results: Investigator assessments of both periocular and perioral wrinkles showed statistically significant improvements over Baseline within minutes of initial application; these positive findings continued to improve through Months 1 and 3 (all P</=0.0003). No treatment-related adverse events were reported.

Conclusions: The results from this study demonstrate that this uniquely formulated line treatment was well tolerated and provided both immediate and long-term improvements in the appearance of fine and coarse wrinkles.

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Figures

Figure 1
Figure 1
Mean reductions from baseline in periocular wrinkles
Figure 2
Figure 2
Mean reductions from baseline in perioral wrinkles
Figures 3a–3d
Figures 3a–3d
Thirty-four-year-old female periocular area at Baseline, Minutes, Month 1, and Month 3
Figures 4a–4d
Figures 4a–4d
Thirty-four-year-old female periocular area at Baseline, Minutes, Month 1, and Month 3
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