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. 2010 Aug;68(4):603-7.
doi: 10.1590/s0004-282x2010000400023.

Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study

Luís Fernando Tirapelli  1 , Paulo Henrique Nasser Andre Bolini, Daniela Pretti da Cunha Tirapelli, Fernanda Maris Peria, Aline Nazareth Paixão Becker, Fabiano Pinto Saggioro, Carlos Gilberto Carlotti Jr
Affiliations
Free article

Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study

Luís Fernando Tirapelli et al. Arq Neuropsiquiatr. 2010 Aug.
Free article

Abstract

The unfavorable prognosis of malignant gliomas can also be explained by the incomplete knowledge of their molecular pathways. Studies regarding the regulatory process of apoptosis in glioblastoma (GBM), the most common malignant glioma, are few, and better knowledge of the expression of pro and anti-apoptotic proteins could collaborate with the development of new treatments founded on molecular basis. The objective of this study was to evaluate by immunohistochemistry the expression of caspase-3 and Bcl-2 in 30 samples of GBMs. The expression of caspase-3 (mean 17.67%) was lower than Bcl-2 (mean 30.92%), a statistically significant result (p<0.0001), suggesting low apoptotic activity in these tumors. Other studies of proteins related to the intrinsic and extrinsic pathway of apoptosis are required to provide additional information of this mechanism in GBMs.

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