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. 2010 Oct;239(10):2547-57.
doi: 10.1002/dvdy.22388.

Atypical molecular profile for joint development in the avian costal joint

B B Winslow  1 , A C Burke
Affiliations

Atypical molecular profile for joint development in the avian costal joint

B B Winslow et al. Dev Dyn. 2010 Oct.

Abstract

Development of synovial joints involves generation of cartilaginous anlagen, formation of interzones between cartilage anlagen, and cavitation of interzones to produce fluid filled cavities. Interzone development is not fully understood, but interzones are thought to develop from skeletogenic cells that are inhibited from further chondrogenic development by a cascade of gene expression including Wnt and Bmp family members. We examined the development of the rarely studied avian costal joint to better understand mechanisms of joint development. The costal joint is found within ribs, is morphologically similar to the metatarsophalangeal joint, and undergoes cavitation in a similar manner. In contrast to other interzones, Wnt14/9a, Gdf5, Chordin, Barx1, and Bapx1 are absent from the costal joint interzone, consistent with the absence of active β-catenin and phosphorylated Smad 1/5/8. However Autotaxin and Noggin are expressed. The molecular profile of the costal joint suggests there are alternative mechanisms of interzone development.

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References

    1. Akiyama H, Chaboissier MC, Martin JF, Schedl A, de Crombrugghe B. The transcrintion factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes & Development. 2002;16:2813–2828. - PMC - PubMed
    1. Archer CW, Dowthwaite GP, Francis-West P. Development of synovial joints. Birth Defects Res C Embryo Today. 2003;69:144–155. - PubMed
    1. Archer CW, Dowthwaite GP, Francis-West P. Joint Formation, in “Fins Into Limbs”. Chicago and London: The University of Chicago Press; 2007. p. 433.
    1. Bachiller D, Klingensmith J, Shneyder N, Tran U, Anderson R, Rossant J, De Robertis EM. The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. Development. 2003;130:3567–3578. - PubMed
    1. Barlow AJ, Bogardi JP, Ladher R, Francis-West PH. Expression of chick Barx-1 and its differential regulation by FGF-8 and BMP signaling in the maxillary primordia. Dev Dyn. 1999;214:291–302. - PubMed

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