Control of DNA replication: a new facet of Hox proteins?
- PMID: 20730947
- DOI: 10.1002/bies.201000048
Control of DNA replication: a new facet of Hox proteins?
Abstract
Hox proteins are well-known as developmental transcription factors controlling cell and tissue identity, but recent findings suggest that they are also part of the cell replication machinery. Hox-mediated control of transcription and replication may ensure coordinated control of cell growth and differentiation, two processes that need to be tightly and precisely coordinated to allow proper organ formation and patterning. In this review we summarize the available data linking Hox proteins to the replication machinery and discuss the developmental and pathological implications of this new facet of Hox protein function.
Similar articles
-
The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions.Nature. 2004 Feb 19;427(6976):749-53. doi: 10.1038/nature02305. Nature. 2004. PMID: 14973489
-
Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.Development. 2006 Jun;133(11):2263-73. doi: 10.1242/dev.02395. Epub 2006 May 3. Development. 2006. PMID: 16672333
-
AP-1 complex is effector of Hox-induced cellular proliferation and transformation.Oncogene. 2000 Oct 26;19(45):5134-41. doi: 10.1038/sj.onc.1203897. Oncogene. 2000. PMID: 11064450
-
PBX proteins: much more than Hox cofactors.Int J Dev Biol. 2008;52(1):9-20. doi: 10.1387/ijdb.072304al. Int J Dev Biol. 2008. PMID: 18033668 Review.
-
Genitourinary functions of Hoxa13 and Hoxd13.J Biochem. 2005 Jun;137(6):671-6. doi: 10.1093/jb/mvi086. J Biochem. 2005. PMID: 16002988 Review.
Cited by
-
HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells.Cancer Res. 2016 Aug 1;76(15):4443-56. doi: 10.1158/0008-5472.CAN-16-0774. Epub 2016 Jun 14. Cancer Res. 2016. PMID: 27302171 Free PMC article.
-
High PLA2 level is correlated with glioblastoma progression via regulating DNA replication.J Cell Mol Med. 2022 Mar;26(5):1466-1472. doi: 10.1111/jcmm.17140. Epub 2022 Feb 15. J Cell Mol Med. 2022. PMID: 35166019 Free PMC article.
-
The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif.Nucleic Acids Res. 2012 Sep 1;40(17):8309-24. doi: 10.1093/nar/gks591. Epub 2012 Jun 22. Nucleic Acids Res. 2012. PMID: 22730300 Free PMC article.
-
Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells.RNA Biol. 2014;11(6):777-87. doi: 10.4161/rna.28828. Epub 2014 Apr 24. RNA Biol. 2014. PMID: 24824789 Free PMC article.
-
Prolonging somatic cell proliferation through constitutive hox gene expression in C. elegans.Nat Commun. 2023 Oct 27;14(1):6850. doi: 10.1038/s41467-023-42644-1. Nat Commun. 2023. PMID: 37891160 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources