Retroperitoneal giant liposarcoma

Abstract

Retroperitoneal liposarcoma is an infrequent, locally aggressive malignancy. We report two cases of huge retroperitoneal liposarcomas. The presence of a palpable abdominal mass was a common symptom of the two patients. Preoperative imaging study showed huge retroperitoneal tumors. Both patients underwent complete surgical resections, and a negative microscopic margin was achieved in both cases. The histopathologic diagnosis was a well-differentiated retroperitoneal liposarcoma. Neither of the two patients developed a recurring tumor during the 1.5 years of follow-up.

Keywords: Liposarcoma; Retroperitoneal neoplasms; Sarcoma.

FIG. 1

(A) Computed tomography (CT) findings. The CT image shows a huge, fat-containing mass originating from the retroperitoneum. Encasement of the left kidney by the mass can be observed. (B) Gross findings. The tumor was a multilobulated, huge, mass-like lesion, measuring about 30×30×8 cm. Serial sections of the specimen revealed a homogeneously yellow colored fatty tissue without other significant solid portions. (C) Microscopic findings showing a well-differentiated liposarcoma, composed of mature adipocytes and a few scattered lipoblasts (H&E, ×400).

FIG. 2

(A) Computed tomography (CT) image showing a large fatty mass with an enhancing solid portion in the left renal subcapsular area. The kidney shows sprayed. (B) The gross specimen consisting of the left kidney and attached soft tissue, weighing 2,120 g. On bisection, a well-encapsulated, multilobulated, yellowish creamy white solid mass was noted, measuring 18×16×13 cm. Focal necrotic areas are seen, making up 10% of the tumor volume. (C) Microscopic findings showing a well-differentiated liposarcoma and mature-appearing adipose tissue with scattered lipoblasts (H&E, ×200).