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. 2010 May-Jun:(3):82-4.

[Laboratory model of hyperlipidemia]

[Article in Russian]
O M Perminova, N N Vol'skiĭ
  • PMID: 20734725

[Laboratory model of hyperlipidemia]

[Article in Russian]
O M Perminova et al. Zh Mikrobiol Epidemiol Immunobiol. 2010 May-Jun.

Abstract

Aim: Approbation of laboratory model of hyperlipidemia induced by multiple administration of poloxamer 407 to hybrid mice (C57BL/6 x DBA/2) F1.

Materials and methods: Two-month-old female mice (C57B1/6 x DBA/2)F1 were used for experiments. Level of dyslipidemia was assessed measuring cholesterol level in serum by method with cholesteroloxidase.

Results: Dosages and timing of administration of the compound for inducing stable moderate hypercholesterolemia were selected. It was discovered that dyslipidemia induced by this method accompanied by reliable increase of neutrophils count in peripheral blood of animals.

Conclusion: Hyperlipidemia induced in mice by administration of poloxamer 407 could be used for convenient experimental model for complex studies of immune system functions during pathophysiologic conditions associated with lipid metabolism disorders.

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