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Comparative Study
. 1978 Mar;43(3):535-8.

[Protein phosphorylation in normal and neoplastic hepatocytes]

[Article in Russian]
M V Nesterova, I M Murtuzaev, T Ia Fraikina, E S Severin
  • PMID: 207359
Comparative Study

[Protein phosphorylation in normal and neoplastic hepatocytes]

[Article in Russian]
M V Nesterova et al. Biokhimiia. 1978 Mar.

Abstract

Partially purified preparations of protein kinase were isolated from the cytoplasm and nuclei of rat liver and hepatoma 27 and characterized in terms of their substrate specificity. The protein kinases from normal liver and hepatoma revealed some differences in phosphorylating protein substrates. Hepatoma protein kinases were found to phosphorylate arginine-rich histones (H3, H4); differences in phosphorylation of histone H1 were revealed. Hepatoma protein kinases phosphorylated the C-terminal fragment of histone H1, whereas normal liver protein kinases produced no such effect. It was assumed that the phosphorylation of histone H1 in rapidly dividing and resting cells is operated through different channels.

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