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Review
. 2010 Sep;24(9):567-70.
doi: 10.1097/BOT.0b013e3181ed298d.

Basic science of intra-articular fractures and posttraumatic osteoarthritis

Todd O McKinley  1 , Joseph Borrelli Jr, Darryl D D'Lima, Bridgette D Furman, Peter V Giannoudis
Affiliations
Review

Basic science of intra-articular fractures and posttraumatic osteoarthritis

Todd O McKinley et al. J Orthop Trauma. 2010 Sep.

Abstract

Intra-articular fractures represent the primary etiologic factor leading to posttraumatic osteoarthritis. The pathomechanisms linking intra-articular fractures to end-stage cartilage destruction are poorly understood. However, fracture-related chondrocyte death has been linked to posttraumatic osteoarthritis. Researchers have made significant progress in understanding the pathomechanical link between injury and chondrocyte death. This article reviews recent basic scientific progress investigating intraarticular fractures and fracture-related chondrocyte death and dysfunction.

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Figures

Figure 1
Figure 1
Percent fair and poor outcomes from tibial plateau fractures over approximately 50 years. Outcomes have changed little over a five decade span.
Figure 2
Figure 2
Percent fair and poor outcomes from acetabular fractures over approximately 30 years. Outcomes have stagnated, especially over the past 20 years.
See this image and copyright information in PMC

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