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. 2010 Oct 7;46(37):7031-3.
doi: 10.1039/c0cc00968g. Epub 2010 Aug 25.

Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily

Stephen R Wecksler  1 , Stefan Stoll, Anthony T Iavarone, Erin M Imsand, Ha Tran, R David Britt, Judith P Klinman
Affiliations

Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily

Stephen R Wecksler et al. Chem Commun (Camb). .

Abstract

pqqD is one of six genes required for PQQ production in Klebsiella pneumoniae. Herein, we demonstrate that PqqD interacts specifically with the radical SAM enzyme PqqE, causing a perturbation in the electronic environment around the [4Fe-4S](+) clusters. This interaction redirects the role for PqqD in PQQ biosynthesis.

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