Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov;7(4):194-200.
doi: 10.1007/s11904-010-0055-3.

Increasing and supporting the participation of persons of color living with HIV/AIDS in AIDS clinical trials

Marya Viorst Gwadz  1 , Pablo Colon, Amanda S Ritchie, Noelle R Leonard, Charles M Cleland, Marion Riedel, DeShannon Bowens, Angela D Banfield, Patricia Chang, Robert Quiles, Donna Mildvan
Affiliations

Increasing and supporting the participation of persons of color living with HIV/AIDS in AIDS clinical trials

Marya Viorst Gwadz et al. Curr HIV/AIDS Rep. 2010 Nov.

Abstract

Persons living with HIV/AIDS (PLHA) of color are under-represented in AIDS clinical trials (ACTs), which may limit the generalizability of research findings and denies many individuals access to high levels of care and new treatments available through ACTs. Disproportionately low rates of recruitment in health care settings and by providers are a major barrier to ACTs for this group. Moreover, PLHA of color are more likely than their white peers to decline to participate, mainly due to fear and mistrust (although willingness is also high), negative social norms about ACTs, and difficulty navigating the unfamiliar ACT system. We describe a small number of successful behavioral and structural interventions to increase the participation of PLHA of color in screening for and enrollment into ACTs. HIV care settings, clinical trials sites, and trial sponsors are uniquely positioned to develop procedures, supports, and trials to increase the proportion of PLHA of color in ACTs.

PubMed Disclaimer

Conflict of interest statement

Disclosure

There are no conflicts of interest.

References

    1. Centers for Disease Control and Prevention. [Accessed June 23, 2010];HIV/AIDS Surveillance Report. 2008; Vol. 20. Available at http://www.cdc.gov/hiv/topics/surveillance/resources/reports/
    1. Centers for Disease Control and Prevention. [Accessed March 28, 2005];HIV/AIDS among African-Americans. Available at http://www.cdc.gov/hiv/pubs/Facts/afam.htm.
    1. Rubin MS, Colen CG, Link BG. Examination of inequalities in HIV/AIDS mortality in the United States from a fundamental cause perspective. Am J Public Health. 2010;100:1053–1059. - PMC - PubMed
    1. National Institute of Allergy and Infectious Diseases (NIAID) [Accessed February 28, 2010];HIV Infection in Minority Populations. Available at http://www.niaid.nih.gov/topics/HIVAIDS/Understanding/Population%20Speci....
    1. Gifford AL, Cunningham WE, Heslin KC, et al. Participation in research and access to experimental treatments by HIV-infected patients. N Engl J Med. 2002;346:1373–1382. - PubMed

Publication types

MeSH terms