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Case Reports
. 2010;33(3):278-80.
doi: 10.1080/10790268.2010.11689708.

Steroid-responsive myeloneuropathy associated with antithyroid antibodies

Recai Turkoglu  1 , Erdem Tuzun
Affiliations
Case Reports

Steroid-responsive myeloneuropathy associated with antithyroid antibodies

Recai Turkoglu et al. J Spinal Cord Med. 2010.

Abstract

Background/objective: To present information about 2 steroid-responsive, antithyroid antibody-positive patients with myeloneuropathy and myelopathy.

Methods: Case reports.

Results: A 48-year-old woman and a 42-year-old man presented with acute onset tetraparesis and magnetic resonance imaging studies showing cervical spinal lesions. Nerve conduction and biopsy studies of the woman were suggestive of a demyelinating polyradiculoneuropathy. Detailed diagnostic workup turned out to be negative for both patients, except for highly elevated antithyroid antibodies with normal thyroid functions and imaging. Both patients responded remarkably well to high-dose steroid treatment, and their symptoms disappeared in a few months. Both patients' antithyroid antibody levels were reduced shortly after steroid treatment and in parallel with the amelioration of symptoms.

Conclusions: Antithyroid antibodies might be associated with acute demyelinating myeloneuropathy or myelopathy pathogenesis and might indicate a good response to steroid treatment in these syndromes.

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Figures

Figure 1
Figure 1
Patient 1. (A) Sagittal T2-weighted magnetic resonance image of the cervical spinal cord shows a hyperintense lesion approximately at the C3 level. (B) The lesion enhances contrast on the T1-weighted sequence.
See this image and copyright information in PMC

References

    1. Goodman BP, Chong BW, Patel AC, Fletcher GP, Smith BE. Copper deficiency myeloneuropathy resembling B12 deficiency: partial resolution of MR imaging findings with copper supplementation. AJNR Am J Neuroradiol. 2006;27(10):2112–2114. - PMC - PubMed
    1. Tristano AG. A case of Sjögren's syndrome with acute transverse myelitis and polyneuropathy in a patient free of sicca symptoms. Clin Rheumatol. 2006;25(1):113–114. - PubMed
    1. Schiess N, Pardo CA. Hashimoto's encephalopathy. Ann N Y Acad Sci. 2008;1142:254–265. - PubMed
    1. Azuma T, Uemichi T, Funauchi M, Doi S, Matsubara T. Myelopathy associated with Hashimoto's disease. J Neurol Neurosurg Psychiatry. 2000;68(5):681–682. - PMC - PubMed
    1. Mahad DJ, Staugaitis S, Ruggieri P, et al. Steroid-responsive encephalopathy associated with autoimmune thyroiditis and primary CNS demyelination. J Neurol Sci. 2005;228(1):3–5. - PubMed

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