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. 2010 Aug:1204:149-55.
doi: 10.1111/j.1749-6632.2010.05522.x.

Reproductive aging in invertebrate genetic models

Marc Tatar  1
Affiliations

Reproductive aging in invertebrate genetic models

Marc Tatar. Ann N Y Acad Sci. 2010 Aug.

Abstract

The invertebrate genetic systems of Caenorhabditis elegans and Drosophila melanogaster are emerging models to understand the underlying mechanisms of reproductive aging and the relationship between reproduction and lifespan. Both animals show progressive decline in egg production beginning at early middle age, caused in part by reduction in germline stem cell proliferation as well as in survival of developing eggs. Molecular genetic analysis reveals that insulin and TGF-beta signaling are regulators of germline stem cell maintenance and proliferation during aging. Furthermore, the lifespan of both C. elegans and D. melanogaster appears to be regulated by signaling that depends on the presence of germline stem cells in the adult gonad. These invertebrate models provide powerful tools to dissect conserved causes of reproductive aging.

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References

    1. te Velde ER, Pearson PL. The variability of female reproductive ageing. Hum. Reprod. Update. 2002;8:141–154. - PubMed
    1. Albert Hubbard EJ, Greenstein D. The Caenorhabditis elegans gonad: A test tube for cell and developmental biology. Developmental Dynamics. 2000;218:2–22. - PubMed
    1. Kadandale P, Singson A. Oocyte production and sperm utilization patterns in semi-fertile strains of Caenorhabditis elegans. BMC Dev. Biol. 2004;4:3. - PMC - PubMed
    1. Hughes SE, et al. Genetic and pharmacological factors that influence reproductive aging in nematodes. PLoS Genet. 2007;3:e25. - PMC - PubMed
    1. Kenyon C, et al. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366:461–464. - PubMed

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