Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Nov;53(5):974-5.
doi: 10.1016/j.jhep.2010.07.001. Epub 2010 Jul 21.

A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis

Junfang Ji  1 , Xin Wei Wang
Affiliations
Comment

A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis

Junfang Ji et al. J Hepatol. 2010 Nov.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
See this image and copyright information in PMC

Comment on

  • Lin28 promotes transformation and is associated with advanced human malignancies.
    Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O'Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH, Daley GQ. Viswanathan SR, et al. Nat Genet. 2009 Jul;41(7):843-8. doi: 10.1038/ng.392. Epub 2009 May 31. Nat Genet. 2009. PMID: 19483683 Free PMC article.

References

    1. Viswanathan SR, Daley GQ, Gregory Rl. Selective blockade of microRNA processing by Lin28. Science. 2008;320:97–100. - PMC - PubMed
    1. Heo I, Joo C, Cho J, Ha M, Han J, Kim VN. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell. 2008;32:276–284. - PubMed
    1. Guo Y, Chen Y, Ito H, Watanabe A, Ge X, Kodama T, et al. Identification and characterization of lin28 homolog B (LIN28B) in human hepatocellular carcinoma. Gene. 2006;384:51–61. - PubMed
    1. Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, et al. Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet. 2009;41:843–848. - PMC - PubMed
    1. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007;131:1109–1123. - PubMed