TRB3: an oxidant stress-induced pseudokinase with a potential to negatively modulate MCP-1 cytokine in diabetic nephropathy
- PMID: 20739396
- PMCID: PMC2980414
- DOI: 10.1152/ajprenal.00479.2010
TRB3: an oxidant stress-induced pseudokinase with a potential to negatively modulate MCP-1 cytokine in diabetic nephropathy
Comment on
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TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1.Am J Physiol Renal Physiol. 2010 Nov;299(5):F965-72. doi: 10.1152/ajprenal.00236.2010. Epub 2010 Jul 21. Am J Physiol Renal Physiol. 2010. PMID: 20660016 Free PMC article.
References
-
- Bowers AJ, Scully S, Boylan JF. SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. Oncogene 22: 2823–2835, 2003 - PubMed
-
- Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300: 1574–1577, 2003 - PubMed
-
- Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S, Danesh FR. Diabetic nephropaqthy: mechanisms of renal disease progression. Exp Biol Med (Maywood) 233: 4–11, 2008 - PubMed
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