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. 2010 Nov;48(11):4102-6.
doi: 10.1128/JCM.00549-10. Epub 2010 Aug 25.

Spoligotypes of Mycobacterium tuberculosis from different Provinces of China

Haiyan Dong  1 , Zhiguang Liu, Bing Lv, Yuanyuan Zhang, Jie Liu, Xiuqin Zhao, Jinghua Liu, Kanglin Wan
Affiliations

Spoligotypes of Mycobacterium tuberculosis from different Provinces of China

Haiyan Dong et al. J Clin Microbiol. 2010 Nov.

Abstract

A total of 2,346 Mycobacterium tuberculosis isolates from 13 provinces in China were genotyped by spoligotyping. Two hundred seventy-eight spoligotypes were identified: 2,153 isolates were grouped into 85 clusters, and the remaining 193 isolates were orphans. Comparison with the SpolDB4.0 database revealed that 118 spoligotypes had shared international type numbers in the database and the other 160 were novel. These 160 novel spoligotypes were assigned to families and subfamilies using the SpotClust program. The most prevalent family was the Beijing family (74.08%), followed by the T family (14.11%). CAS family strains were found only in the Xinjiang and Tibet regions, while EAI family strains were found only in Fujian Province. In conclusion, the present study of the M. tuberculosis population in China demonstrated that Beijing family isolates are the most prevalent strains in China and that they exhibit geographical variation. Furthermore, many new spoligotypes were found in this study.

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Figures

FIG. 1.
FIG. 1.
Map of China showing the distribution of M. tuberculosis isolates included in this study (the numbers indicate the absolute number of isolates per province).
See this image and copyright information in PMC

References

    1. Ahmed, N., N. Z. Ehtesham, and S. E. Hasnain. 2009. Ancestral Mycobacterium tuberculosis genotypes in India: implications for TB control programmes. Infect. Genet. Evol. 9:142-146. - PubMed
    1. Bhanu, N. V., D. van Soolingen, J. D. van Embden, L. Dar, R. M. Pandey, and P. Seth. 2002. Predominace of a novel Mycobacterium tuberculosis genotype in the Delhi region of India. Tuberculosis 82:105-112. - PubMed
    1. Bifani, P. J., B. Mathema, N. E. Kurepina, and B. N. Kreiswirth. 2002. Global dissemination of the Mycobacterium tuberculosis W-Beijing family strains. Trends Microbiol. 10:45-52. - PubMed
    1. Brosch, R., S. V. Gordon, M. Marmiesse, P. Brodin, C. Buchrieser, K. Eiglmeier, T. Garnier, C. Gutierrez, G. Hewinson, K. Kremer, L. M. Parsons, A. S. Pym, S. Samper, D. van Soolingen, and S. T. Cole. 2002. A new evolutionary scenario for the Mycobacterium tuberculosis complex. Proc. Natl. Acad. Sci. U. S. A. 99:3684-3689. - PMC - PubMed
    1. Brudey, K., J. R. Driscoll, L. Rigouts, W. M. Prodinger, A. Gori, S. A. Al-Hajoj, C. Allix, L. Aristimuno, J. Arora, V. Baumanis, L. Binder, P. Cafrune, A. Cataldi, S. Cheong, R. Diel, C. Ellermeier, J. T. Evans, M. Fauville-Dufaux, S. Ferdinand, D. Garcia de Viedma, C. Garzelli, L. Gazzola, H. M. Gomes, M. C. Guttierez, P. M. Hawkey, P. D. van Helden, G. V. Kadival, B. N. Kreiswirth, K. Kremer, M. Kubin, S. P. Kulkarni, B. Liens, T. Lillebaek, M. L. Ho, C. Martin, I. Mokrousov, O. Narvskaia, Y. F. Ngeow, L. Naumann, S. Niemann, I. Parwati, Z. Rahim, V. Rasolofo-Razanamparany, T. Rasolonavalona, M. L. Rossetti, S. Rusch-Gerdes, A. Sajduda, S. Samper, I. G. Shemyakin, U. B. Singh, A. Somoskovi, R. A. Skuce, D. van Soolingen, E. M. Streicher, P. N. Suffys, E. Tortoli, T. Tracevska, V. Vincent, T. C. Victor, R. M. Warren, S. F. Yap, K. Zaman, F. Portaels, N. Rastogi, and C. Sola. 2006. Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology. BMC Microbiol. 6:23. - PMC - PubMed

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