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Case Reports
. 2010 Feb 27;3(1):49-53.
doi: 10.1159/000287639.

Unusual Osteoblastic Secondary Lesion as Predominant Metastatic Disease Spread in Two Cases of Uterine Leiomyosarcoma

Loredana Miglietta  1 , Luciano Canobbio, Maria Angela Parodi, Luca Anselmi
Affiliations
Case Reports

Unusual Osteoblastic Secondary Lesion as Predominant Metastatic Disease Spread in Two Cases of Uterine Leiomyosarcoma

Loredana Miglietta et al. Case Rep Oncol. .

Abstract

Uterine smooth muscle tumors range from benign leiomyomata to low- and high-grade leiomyosarcomas. A leiomyosarcoma is a rare malignant smooth muscle tumor that infrequently metastasizes to the bone. In fact, initial presentation or recurrence as osseous metastases is extremely uncommon in patients with a history of leiomyosarcoma. On imaging, these bone lesions generally appear as lytic foci. The authors report here two cases of osteoblastic bone lesions in leiomyosarcoma of the uterus with predominant metastatic lesions localized in the bone.

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Figures

Fig. 1
Fig. 1
a Smooth muscle tumor cells arranged in fascicles. b Immunostaining positive for desmin.
Fig. 2
Fig. 2
a Histologically stained leiomyosarcoma cells with cigar-shaped nuclei and eosinophilic cytoplasm. b Neoplastic cells with several mitotic figures (original magnification 60 × HE)
See this image and copyright information in PMC

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