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. 1978 Jun 8;189(3):403-7.
doi: 10.1007/BF00209129.

Investigations into the mechanism of hormone release by rat adrenocortical cells

G G Nussdorfer, G Mazzocchi, G Neri, C Robba

Investigations into the mechanism of hormone release by rat adrenocortical cells

G G Nussdorfer et al. Cell Tissue Res. .

Abstract

Vinblastine treatment blocks corticosterone release from rat adrenal zona fasciculata without impairing hormone synthesis, and induces the formation of acid phosphatase-positive granular clumps at the juxta-sinusoidal pole of the cells. Autoradiography shows that ACTH administration to vinblastine-treated animals mobilizes the 3H-cholesterol stored in the lipid droplets and leads to a noticeable labelling of the granular clumps. The possible significance of these granules is discussed.

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