[Tumor lectinology--status and perspectives of clinical application]

Abstract

A detailed knowledge of the mechanisms of molecular recognition is a prerequisite to rationally improved diagnostic and therapeutic procedures in diseases. In addition to sequences of amino acids, carbohydrate structures apparently store biological information that is thought to be relevant for physiologically important processes. Such ligands, namely the carbohydrate part of cellular glycoconjugates, can be recognized by specific endogenous binding proteins like lectins. If their presence can be reliably ascertained and correlated to the clinical course of the disease, e.g. in oncology, lectinology may help to define a yet undisclosed role for this class of proteins in tumor progression and spread.