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. 1990;39(4):391-4.
doi: 10.1007/BF00315416.

Effect of exercise on propranolol pharmacokinetics

S Frank  1 , S M Somani, M Kohnle
Affiliations

Effect of exercise on propranolol pharmacokinetics

S Frank et al. Eur J Clin Pharmacol. 1990.

Abstract

The effect of submaximal exercise on the pharmacokinetics of low dose intravenous propranolol was studied in 15 healthy human subjects. There was a wide individual variation in the results for each subject and a large difference in the degree of changes with exercise. The effect of exercise on the pharmacokinetics of propranolol, a flow limited drug, is marked but variable. This phenomenon may have profound effects on patients taking the drug regularly who exercise intermittently and drug doses may have to be adjusted.

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