Case Reports
Evidence for involvement of a Robertsonian translocation 13 chromosome in formation of a ring chromosome 13
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- PMID: 2077349
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Case Reports
Evidence for involvement of a Robertsonian translocation 13 chromosome in formation of a ring chromosome 13
Mol Biol Med.
1990 Dec.
Abstract
We have used molecular and cytogenetic methods to study the derivation of a ring chromosome 13 in the fetus of a woman mosaic for a translocation chromosome 13. DNA analysis showed that the translocation chromosome was a Robertsonian translocation, not an isochromosome. We suggest that the ring is derived from the translocation chromosome by breaks in both long arms and subsequent reunion, r(13) (q12q14).
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