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Case Reports
. 1990 Nov;150(1):40-2.
doi: 10.1007/BF01959478.

Immunological aspects of progeria (Hutchinson-Gilford syndrome) in a 15-month-old child

M Harjacek  1 , D Batinić, V Sarnavka, B Uzarević, D Mardesić, M Marusić
Affiliations
Case Reports

Immunological aspects of progeria (Hutchinson-Gilford syndrome) in a 15-month-old child

M Harjacek et al. Eur J Pediatr. 1990 Nov.

Abstract

A thorough analysis of the immunological status was conducted in a 15-month-old child with progeria (Hutchinson-Gilford syndrome). Total leukocyte and neutrophil counts were slightly increased, and monocytes were decreased. Percentage and numbers of CD4+ cells in the blood were mildly decreased as well as the CD4/CD8 cell ratio. CD20 (B-cell marker) bearing cells and cells bearing Ia-antigens were increased, as well as CD16 and CD56 marker-bearing cells (natural-killer cells, NK). Lymphocyte proliferation upon stimulation with phytohaemagglutinin and purified protein derivative were decreased, and with pokeweed mitogen increased. NK cell activity appeared increased, particularly at lower effector: target cell ratios.

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