doi: 10.1021/np1001913.
Polyacetylenes from the roots of Polyalthia debilis
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- PMID: 20795741
- DOI: 10.1021/np1001913
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Polyacetylenes from the roots of Polyalthia debilis
J Nat Prod.
.
Abstract
Six new linear polyacetylenic C25 and C27 acetogenins (1-6), named debilisones A-F, have been isolated from a methanol extract of roots of Polyalthia debilis. Structures of these compounds were determined by spectroscopic techniques. The absolute configuration at C-17 of 2 was assigned by the modified Mosher's method. Compounds 2, 3, and 5 exhibited moderate antimycobacterial activity against Mycobacterium tuberculosis with MIC values of 25.0, 12.5, and 25.0 microg/mL, respectively.
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