Studies in genetically modified mice suggest novel mechanisms of mood regulation
- PMID: 20797461
- PMCID: PMC2929529
- DOI: 10.1016/j.biopsych.2010.07.020
Studies in genetically modified mice suggest novel mechanisms of mood regulation
Comment in
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Gamma-aminobutyric acidergic deficits cause melancholic depression: a reply to Markou and Geyer.Biol Psychiatry. 2011 Feb 15;69(4):e13-4; author reply e15-6. doi: 10.1016/j.biopsych.2010.09.054. Epub 2010 Dec 3. Biol Psychiatry. 2011. PMID: 21126731 No abstract available.
Comment on
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gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression.Biol Psychiatry. 2010 Sep 15;68(6):512-20. doi: 10.1016/j.biopsych.2010.04.024. Epub 2010 Jul 1. Biol Psychiatry. 2010. PMID: 20579975 Free PMC article.
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Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior.Biol Psychiatry. 2010 Sep 15;68(6):503-11. doi: 10.1016/j.biopsych.2010.04.031. Epub 2010 Jun 29. Biol Psychiatry. 2010. PMID: 20591414 Free PMC article.
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References
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- Sanacora G, Gueorguieva R, Epperson CN, Wu Y-T, Appel M, Rothman DL, Krystal JH, Mason GF. Subtype-specific alterations of g-aminobutyric acid and glutamate in patients with major depression. Archives of General Psychiatry. 2004;61:705–713. - PubMed
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- Cryan JF, Kaupmann KC. Don’t worry ‘B’ happy!: a role for GABAB receptors in anxiety and depression. Trends in Pharmacological Sciences. 2005;26(1):36–43. - PubMed
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- Mukherjee S, Coque L, Cao J-L, Kumar J, Chakravarty S, Asaithamby A, Graham A, Gordon E, Enwright JF, II, DiLeone RJ, Birnbaum SG, Cooper DC, McClung CA. Knock down of CLOCK in the VTA through RNAi results in a mixed state of mania and depression-like behavior. Biological Psychiatry. 2010 In press. - PMC - PubMed
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