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Comment
. 2010 Aug 27;39(4):485-6.
doi: 10.1016/j.molcel.2010.08.005.

GTP: gatekeeper for autophagy

Isabelle Beau  1 , Patrice Codogno
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Free article
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GTP: gatekeeper for autophagy

Isabelle Beau et al. Mol Cell. .
Free article

Abstract

Chaperone-mediated autophagy (CMA) is involved in cellular quality control, and in the response to stress, deterioration in CMA contributes to the aging phenotype and to various disorders. The paper by Bandyopadhyay et al. in this issue of Molecular Cell demonstrates the role of GTP binding by elongation factor 1 alpha (EF1alpha) in regulating the lysosomal uptake of CMA substrates.

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