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Comparative Study
. 2011 Jan;95(1):413-6.
doi: 10.1016/j.fertnstert.2010.07.1051. Epub 2010 Aug 24.

Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization

Mariona Rius  1 , Gemma Daina, Albert Obradors, Laia Ramos, Esther Velilla, Sílvia Fernández, Olga Martínez-Passarell, Jordi Benet, Joaquima Navarro
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Free article
Comparative Study

Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization

Mariona Rius et al. Fertil Steril. 2011 Jan.
Free article

Abstract

The short comparative genomic hybridization (short-CGH) method was used to perform a comprehensive cytogenetic study of isolated blastomeres from advanced maternal age embryos, discarded after fluorescent in situ hybridization (FISH) preimplantation genetic screening (PGS), detecting aneuploidies (38.5% of which corresponded to chromosomes not screened by 9-chromosome FISH), structural aberrations (31.8%), and mosaicism (77.3%). The short-CGH method was subsequently applied in one PGS, achieving a twin pregnancy.

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