Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Dec;39(6):1647-55.
doi: 10.1093/ije/dyq126. Epub 2010 Aug 25.

Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study

Stephen O Crawford  1 , Ron C Hoogeveen, Frederick L Brancati, Brad C Astor, Christie M Ballantyne, Maria Inês Schmidt, Jeffery Hunter Young
Affiliations

Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study

Stephen O Crawford et al. Int J Epidemiol. 2010 Dec.

Abstract

Background: Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies.

Methods: To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.

Results: The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend <0.0001). Following adjustment for demographic factors, physical activity, body mass index and waist circumference, the relative odds of type 2 diabetes across lactate quartiles were 0.98 [95% confidence interval (CI) 0.59-1.64], 1.64 (95% CI 1.03-2.64) and 2.23 (95% CI 1.38-3.59), respectively. Furthermore, lactate was associated with higher fasting glucose among non-diabetic adults.

Conclusions: Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Probability of type 2 diabetes across the distribution of blood lactate among 1749 older adults. Bars represent the distribution of lactate. The solid line denotes the predicted probability of type 2 diabetes (right axis); 95% CIs are shaded in grey; Triangles (bottom) represent the individual cases of type 2 diabetes
Figure 2
Figure 2
Association of triglyceride–HDL ratio with plasma lactate quartile among non-diabetics. Beta coefficients are adjusted for age, sex, high-IMT status, field centre, BMI and fasting glucose. Lactate quartiles are represented by the median lactate value within each quartile
See this image and copyright information in PMC

References

    1. Gerbitz KD, Gempel K, Brdiczka D. Mitochondria and diabetes—genetic, biochemical, and clinical implications of the cellular energy circuit. Diabetes. 1996;45:113–26. - PubMed
    1. Robinson BH. Lactic acidemia and mitochondrial disease. Mol Genet Metab. 2006;89:3–13. - PubMed
    1. Simoneau JA, Colberg SR, Thaete FL, Kelley DE. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J. 1995;9:273–78. - PubMed
    1. Kelley DE, Slasky BS, Janosky J. Skeletal muscle density: effects of obesity and non-insulin-dependent diabetes mellitus. Am J Clin Nutr. 1991;54:509–15. - PubMed
    1. Del PS, Bonadonna RC, Bonora E, et al. Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus. J Clin Invest. 1993;91:484–94. - PMC - PubMed

Publication types

MeSH terms