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Comment
. 2010 Sep 7;107(36):15666-7.
doi: 10.1073/pnas.1007944107. Epub 2010 Aug 23.

Mouse retroviruses and chronic fatigue syndrome: Does X (or P) mark the spot?

Valerie Courgnaud  1 , Jean-Luc Battini, Marc Sitbon, Andrew L Mason
Affiliations
Comment

Mouse retroviruses and chronic fatigue syndrome: Does X (or P) mark the spot?

Valerie Courgnaud et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
MLV-related sequences in CFS patients. (A) Virions are represented with color-coded genomic RNA caged in hexagonal gag-encoded capsids, with glycogag and the env-encoded envelope (Env) glycoproteins represented as zigzag lines, circles, and sticks, respectively. Env determines tropism for mouse and not human cells (ecotropic), nonmouse cells (xenotropic), or both cell types (polytropic). XMRV seems to be a xenotropic/polytropic recombinant that may both lack glycogag (see below) and require complementation with another infectious agent to spread in humans. (B) Schematic MLV proviral DNA genome with the glycogag, gag, and env CTG and ATG translation initiation codons. The xenotropic (black) or polytropic (gray) origin for env, when known, and the glycogag leader sequence (upstream of the gag ATG) are shown with the corresponding in-frame 24- (xenotropic) or 9-bp (polytropic) deletion and a frameshift (lightning) that leads to a stop codon (star). Sequences reported in PNAS (6) do not allow predictions on glycogag production.
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