Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Sep 7;107(36):15666-7.
doi: 10.1073/pnas.1007944107. Epub 2010 Aug 23.

Mouse retroviruses and chronic fatigue syndrome: Does X (or P) mark the spot?

Valerie Courgnaud  1 , Jean-Luc Battini, Marc Sitbon, Andrew L Mason
Affiliations
Comment

Mouse retroviruses and chronic fatigue syndrome: Does X (or P) mark the spot?

Valerie Courgnaud et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
MLV-related sequences in CFS patients. (A) Virions are represented with color-coded genomic RNA caged in hexagonal gag-encoded capsids, with glycogag and the env-encoded envelope (Env) glycoproteins represented as zigzag lines, circles, and sticks, respectively. Env determines tropism for mouse and not human cells (ecotropic), nonmouse cells (xenotropic), or both cell types (polytropic). XMRV seems to be a xenotropic/polytropic recombinant that may both lack glycogag (see below) and require complementation with another infectious agent to spread in humans. (B) Schematic MLV proviral DNA genome with the glycogag, gag, and env CTG and ATG translation initiation codons. The xenotropic (black) or polytropic (gray) origin for env, when known, and the glycogag leader sequence (upstream of the gag ATG) are shown with the corresponding in-frame 24- (xenotropic) or 9-bp (polytropic) deletion and a frameshift (lightning) that leads to a stop codon (star). Sequences reported in PNAS (6) do not allow predictions on glycogag production.
See this image and copyright information in PMC

Comment on

References

    1. Urisman A, et al. Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoS Pathog. 2006;2:e25. - PMC - PubMed
    1. Lombardi VC, et al. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science. 2009;326:585–589. - PubMed
    1. Levy JA. Xenotropic viruses: Murine leukemia viruses associated with NIH Swiss, NZB, and other mouse strains. Science. 1973;182:1151–1153. - PubMed
    1. Schlaberg R, Choe DJ, Brown KR, Thaker HM, Singh IR. XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors. Proc Natl Acad Sci USA. 2009;106:16351–16356. - PMC - PubMed
    1. Switzer WM, et al. Absence of evidence of xenotropic murine leukemia virus-related virus infection in persons with chronic fatigue syndrome and healthy controls in the United States. Retrovirology. 2010;7:57. - PMC - PubMed

Publication types

LinkOut - more resources