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. 2009 Sep 13:2009:972178.
doi: 10.4061/2009/972178.

Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress

Anil Kumar  1 , Samrita Dogra, Atish Prakash
Affiliations

Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress

Anil Kumar et al. Int J Alzheimers Dis. .

Abstract

Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer's disease. The present study was designed to investigate the neuroprotective effects of Centella asiatica against colchicine-induced memory impairment and oxidative damage in rats. Colchicine (15 mug/5 muL) was administered intracerebroventricularly in the lateral ventricle of male wistar rats. Morris water maze and plus-maze performance tests were used to assess memory performance tasks. Various biochemical parameters such as lipid peroxidation, nitrite, reduced glutathione, glutathione-S-transferase, superoxide dismutase, acetylcholinesterase were also assessed. ICV colchicine resulted marked memory impairment and oxidative damage. Chronic treatment with Centella asiatica extract (150 and 300 mg/kg, p.o.) for a period of 25 days, beginning 4 days prior to colchicine administration, significantly attenuated colchicine-induced memory impairment and oxidative damage. Besides, Centella asiatica significantly reversed colchicines administered increase in acetylcholinesterase activity. Thus, present study indicates protective effect of Centella asiatica against colchicine-induced cognitive impairment and associated oxidative damage.

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Figures

Figure 1
Figure 1
Centella asiatica (CA; 150 and 300 mg/kg, PO) on locomotor activity in intracerebroventricular colchicines- (COL-) injected rats. Values are mean ± SEM. Data was analyzed by two-way anova (n = 12 in each group).
Figure 2
Figure 2
Centella asiatica (CA; 150 and 300 mg/kg, PO) on acetyl cholinesterase activity in Intracerebroventricular colchicines- (COL-) treated rats. Values are mean ± SEM; a P < .05 as compared to artificial cerebrospinal fluid- (aCSF-) injected group; b P < .05 as compared to colchicine treated group; c P < .05 as compared to CA (150) + COL group; (one-way ANOVA followed by Turkey's test for multiple comparisons). Note: aCSF: artificial cerebrospinal fluid; COL: colchicine; CA: Centella asiatica
See this image and copyright information in PMC

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