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. 2010 Dec;66(12):1298-303.
doi: 10.1002/ps.2013. Epub 2010 Aug 26.

Identification of new limonoids from Swietenia and their biological activity against insects

Robert Fowles  1 , Baldwin Mootoo, Russel Ramsewak, Ayub Khan, Adesh Ramsubhag, William Reynolds, Muraleedharan Nair
Affiliations

Identification of new limonoids from Swietenia and their biological activity against insects

Robert Fowles et al. Pest Manag Sci. 2010 Dec.

Abstract

Background: Natural limonoids are one group of compounds being studied for their insecticidal properties. To discover new limonoids with better activities, analogs were prepared via acylation and hydrolysis, and bioassayed.

Results: Analogs were identified using one- and two-dimensional (COSY, HMQC and HMBC) (1) H and (13) C NMR, IR and MS. 3-O-Isovalerylswietenolide (13) and 3-O-isobutyrylswietenolide (14) showed excellent antifeedant activity, with DC(50) values of 0.19 and 0.009 mg L(-1) respectively, compared with the natural limonoid swietenolide (80.6 mg L(-1) ) against fourth-instar Spodoptera frugiperda (JE Smith) larvae.

Conclusion: This work shows that limonoid analogs prepared through semi-synthesis can be used as lead compounds for the development of new insecticides.

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